PAXLOVID isan investigational SARS-CoV-2 protease inhibitor antiviral therapy, specifically designed to be administered orally so that it can be prescribed at the first sign of infection or at first awareness of an exposure, potentially helping patients avoid severe illness which can lead to hospitalization and death. The company has entered into advance purchase agreements with multiple countries and is in negotiations with several others. The Y-BOCS (Yale-Brown Obsessive Compulsive Scale) will be used to assess change from baseline. Approximately 1060 subjects will be randomized globally. The description for each category listed in the NHSE service specification has been included in the tool. CGIC (Clinical global impression of change) is an overall evaluation of response to treatment, conducted by investigator using 7-point rating scale, ranging from 1 (very much improved), to 7 (very much worse) Patients Global Impression of Change at Week 52 [ Time Frame: From randomisation to Study Week 52 ] Researchers from Kings College London, funded by the NIHR, have developed practical guidance to aid, The POSITIVE Outcomes tool can support people with HIV and help healthcare professionals understand. In neurological rehabilitation, patients can be present with diverse combinations of physical, cognitive and behavioural impairments, which may impact on rehabilitation potential. Objectives: To expand the ability to assess physical frailty by developing a Clinical Global Impression of Change in Physical Frailty (CGIC-PF) instrument. It is useful for clinicians to have at least a basic familiarity with rating scales that are commonly used in clinical trials. The computer outputs include an overall dependency score, calculation of total therapy time per patient. The total score is defined as the average of all 32 questions in the AQLQ(S)+12 questionnaire. Martins C, Sayegh S, Faundez A, Fourchet F, Bothorel H. Biology (Basel). Their purpose is to inform the immediate plan for care on the acute ward and to identify problems likely to require furthermore detailed evaluation by members of the multi-disciplinary team and so trigger appropriate referrals. J Clin Epidemiol. ), unlawful and unfair business practices under the Unfair Competition Law (UCL) (Bus. The tool comprises of 18 domains each with 3 columns containing level of need categories. This paper examined the effects on globalization in terms of mobility, trade, travel, global health, and the countries most impacted. Pfizer has also begun and will continue to invest up to approximately $1 billion to support the manufacturing and distribution of this investigational treatment, including exploring potential contract manufacturing options to help ensure access across low- and middle-income countries, pending regulatory authorization. Any legal analysis, legislative updates or other content and links should not be construed as legal or professional advice or a substitute for such advice. Each patient was randomized (1:1) to receive PAXLOVID or placebo orally every 12 hours for five days. Microsoft is quietly building a mobile Xbox store that will rely on Activision and King games. DOJ Prosecutes Attempted Collusion among Business Competitors for NFT Insider Trading Charge Doesnt Require the NFT To Be a Security, The Role of Economic Analysis in UK Shareholder Actions, CFTC Whistleblower Programs Annual Report Details Record Year. News for Hardware, software, networking, and Internet media. It is an ordinal scale incorporating activities of daily living, safety awareness, behavioural management and communication. 2022 Sep 27;12(10):1594. doi: 10.3390/jpm12101594. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Arthritis Rheum. (Clinical Trial). Hypnosis is a human condition involving focused attention (the selective attention/selective inattention hypothesis, SASI), reduced peripheral awareness, and an enhanced capacity to respond to suggestion.. Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Eur J Pain. Go to Subject has previously been randomized in a FX-322 clinical trial. 4 = No change. [t]herefore, most, if not all, of the almost 5,500 potential class members would be unable to maintain their CMIA claims against [Defendant] unless they could establish that an unauthorized party viewed their confidential medical information and that [Defendants] s negligence caused this breach of confidentiality. Definition of Stroke. The BI can be used to determine a baseline level of functioning and can be used to monitor improvements in activities of daily living over time. The latest Lifestyle | Daily Life news, tips, opinion and advice from The Sydney Morning Herald covering life and relationships, beauty, fashion, health & wellbeing Please enable it to take advantage of the complete set of features! 2020 Oct 13;21(1):266. doi: 10.1186/s12931-020-01526-6. Liebowitz MR. Subjects will be randomized in a 1:1 ratio to either tezepelumab or matching placebo both administered subcutaneously. Categories of "much improved" and "very much improved" were used as determinants of a clinically important difference and the relationship to the PI-NRS was explored using graphs, box plots, and sensitivity/specificity analyses. About the Phase 2/3 EPIC-HR Study Interim Analysis. What does CGIC stand for? This decision is notable as this was the first ruling from any California appellate court addressing class certification issues in the context of claims under CMIA and will impact other cases going forward. Clinical Global Impressions-Improvement (CGI-I) Rate total improvement whether or not, in your judgment, it is due entirely to drug treatment. The Clinical Global Impression Scale (CGI) ( 8) is one of the most widely used brief rating scales in mental health and pharmaceutical trials. Meditation is practiced in numerous religious traditions. WC2R 2LS Parting Advice: Judge Drain Rules That Dividends Paid From the Proceeds of Safe- Value-Based Care Conference 2022: Hot Topics and Trends, 2022 West Coast Forum - Beverly Hills, CA, Mitigating Title IX Liability in Athletic Fundraising Policies and Procedures, Trade Secrets, Restrictive Covenants, and No-Poach Agreements in Health Care. About Pfizer: Breakthroughs That Change Patients Lives. There is also no evidence suggesting that other unauthorized parties viewed the information in the patient spreadsheet or that it was posted or disclosed in a public forum . Has The SEC Conflated Indemnification And Insurance? In addition to the domains, there are supplementary questions based on clinical impression on the service level required, potential category of need and estimated duration of in-patient rehabilitation stay. Gabapentin for chronic neuropathic pain in adults. Enrolled individuals had a laboratory-confirmed diagnosis of SARS-CoV-2 infection within a five-day period with mild to moderate symptoms and were required to have at least one characteristic or underlying medical condition associated with an increased risk of developing severe illness from COVID-19. Researchers at King's developed the guide with children and young people and Marie Curie. Hello, and welcome to Protocol Entertainment, your guide to the business of the gaming and media industries. Standing Steadiness and Asymmetry after High Tibial Osteotomy Surgery: A 2 Year Follow-Up Study. In The Zone? The changes in the PI-NRS from baseline to the endpoint were compared to the PGIC for each subject. Read articles and watch video on the tech giants and innovative startups. Subjects will receive tezepelumab, or placebo, administered via subcutaneous injection at the study site, over a 52-week treatment period. Developed during the COVID-19 pandemic, these tools are also expected to be useful in future for any patient following prolonged treatment in intensive care. The Neurological Impairment Scale (NIS) forms part of the standard minimum dataset for theUK FIM+FAM. Goal analysis from four large international studies has identified six common categories for treatment goals. Read articles and watch video on the tech giants and innovative startups. The Alice Test for Patent Ineligibility in Practice, Part Two: The Australian Government Commits to Protecting First Nations Visual Art. French Insider Episode 17: The Ins and Outs of International EPA Awards Nearly $750,000 to Fund PFAS Exposure Pathways Research, Chemical Hair Straightener Cancer Lawsuits, Why You Need to Focus on Building Your Personal Brand Today. The category of need currently remains a clinical decision; however, there is reasonable indication that a total PCAT score of 19-24 indicates Category C needs, 25-29 category B needs and a total PCAT score of 30 category A needs. It was developed on the basis of previous research led by Kings College London over a decade or more, including extensive analysis of goals and other outcomes from several large international studies. Mean change from baseline in AQLQ(S)+12 as compared to placebo at Week 52. Individual Participant Data (IPD) Sharing Statement: AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. EPIC-SR includes a cohort of vaccinated patients who have an acute breakthrough symptomatic COVID-19 infection and who have risk factors for severe illness. The RCS provides a simple overall measure of care, nursing, therapy, medical and equipment needs, and is designed to offer crude banding of complexity. California Court of Appeal Dismantles Rounding Where Accurate Defense Contractors - Check Your Non-Disclosure Agreements for Three Notable Antitrust & Tech Updates That May Have Flown Under Justice Department Obtains Permanent Injunction Blocking Penguin SEC Awards Whistleblower $10 Million After Returning Money to Harmed Uncovering Juror Bias, Counteracting Nuclear Verdicts, & the Future of Fall Back: Westchesters Pay Transparency Law Takes Effect on November 6, 2022. What is the abbreviation for Clinical Global Impressions of Change? Despite, or perhaps because of, its simplicity, it is one of the most widely used scales in clinical trials in psychopharmacology. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03347279. Crypto Showdown: SECs Lawsuit Against Ripple Labs Reaches Critical BIS Implements New Chinese Supercomputer and Semiconductor International Trade Practice at Squire Patton Boggs. 1 = Very much improved. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. AQLQ(S)+12 is a 7-point scale questionnaire, ranging from 7 (no impairment) to 1 (severe impairment). The Indexwas developed by Mahoney and Barthel in 1965 and is widely used in rehabilitation. Patient global impression (PGI) is a validated global ratingofchange scale used to assess subjective patients response based on the individual feeling of improvement or deterioration after receiving a treatment [ 8 ], [ 9 ]. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Co-administration with a low dose of ritonavir helps slow the metabolism, or breakdown, of PF-07321332 in order for it to remain active in the body for longer periods of time at higher concentrations to help combat the virus. As is often the case in data breach cases, Plaintiffs UCL claim was predicated on her statutory and negligence claims. 2001 Nov;94(2):131-132. doi: 10.1016/S0304-3959(01)00371-2. Cochrane Database Syst Rev. Clinical Global Impression of Change (CGIC). The scheduled interim analysis showed an 89% reduction in risk of COVID-19-related hospitalization or death from any cause compared to placebo in patients treated within three days of symptom onset (primary endpoint); 0.8% of patients who received PAXLOVID were hospitalized through Day 28 following randomization (3/389 hospitalized with no deaths), compared to 7.0% of patients who received placebo and were hospitalized or died (27/385 hospitalized with 7 subsequent deaths). Buchbinder R, Bombardier C, Yeung M, Tugwell P. Which outcome measures should be used in rheumatoid arthritis clinical trials? Provides input to strategic decisions that affect the functional area of responsibility. The self-report measure Patient Global Impression of Change (PGIC) reflects a patients belief about the efficacy of treatment. POS consists of ten items that assess physical symptoms, emotional, psychological, and spiritual needs, a provision of information and support resulting in individual item scores and overall profile scores. FOIA Pain. Given the continued global impact of COVID-19, we have remained laser-focused on the science and fulfilling our responsibility to help healthcare systems and institutions around the world while ensuring equitable and broad access to people everywhere.. The Palliative Care Outcome Scale (POS) was developed for use with patients with advanced disease, and to improve outcome measurement by evaluating many essential and important outcomes in palliative care. sharing sensitive information, make sure youre on a federal Plaintiff sought to certify a putative class and demanded compensatory and punitive damages for Defendants alleged negligence in failing to secure plaintiffs personal information. Global Biliary Atresia Treatment Market-Impact of Coronavirus (COVID-19) Pandemic The COVID-19 pandemic has highly impacted research and clinical trials of biliary atresia. In addition to the domains, there are supplementary questions based on clinical impression on the service level required, potential category of need and estimated duration of in-patient rehabilitation stay. doi: 10.1002/14651858.CD010567.pub2. WPAI+CIQ (Work Productivity and Activity Impairment plus Classroom Impairment Questionnaire) contains 10 questions. Epub 2009 Aug 8. The Patient Global Impression scale (PGI), also known as Subject Global Impression (SGI), is the PRO counterpart to the Clinical Global Impressions scale, (CGI), which was published in 1976 by the National Institute of Mental Health (US). The Patient Global Impression scale (PGI), also known as Subject Global Impression (SGI), is the PRO counterpart to the Clinical Global Impressions scale, (CGI), which was published in 1976 by the National Institute of Mental Health (US). After the litigation was underway, the trial court eventually issued an order denying class certification. PF-07321332 inhibits viral replication at a stage known as proteolysis, which occurs before viral RNA replication. Get the latest health news, diet & fitness information, medical research, health care trends and health issues that affect you and your family on ABCNews.com Unless otherwise noted, attorneys are not certified by the Texas Board of Legal Specialization, nor can NLR attest to the accuracy of any notation of Legal Specialization or other Professional Credentials. Epub 2011 Mar 27. 125 Clinical Global Impression (CGI) Reference: Guy W,editor.ECDEU Assessment Manual for Psychopharmacology.1976. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Accessibility Before History of a clinically significant infection. Hypnosis is a human condition involving focused attention (the selective attention/selective inattention hypothesis, SASI), reduced peripheral awareness, and an enhanced capacity to respond to suggestion.. Mean change from baseline in FEV1 as compared to placebo at Week 52. 3 = Minimally improved. Would you like email updates of new search results? Proportion of subjects with at least one asthma exacerbation associated with emergency room visit or hospitalisation as recorded by the investigator in the CRF. https://astrazenecagroup-dt.pharmacm.com/DT/Home. The changes in the PI-NRS from baseline to the endpoint were compared to the PGIC for each subject. The annualized exacerbation rate is based on exacerbations associated with hospitalisations or ER visits, where hospitalisation and ER visits adjudicated to be asthma related are added, and those adjudicated to not be asthma related are removed from analyses. 2 = Much improved. Helping persons with OCD deal with the coronavirus pandemic, The relationship between COVID-19 and mental disorders (and what we should do about it), BEST books on Evidence-Based Medicine (EBM), Quick Inventory of Depressive Symptomatology (QIDS-SR). Bethesda, MD 20894, Web Policies To be a Clinical Data Manager typically requires 3+ years of managerial experience. Challenges in the Valuation of VC-Backed Companies: Why Relying on NYDFSs $4.5 Million EyeMed Cyber Settlement Reminder To Industry, ESG Considerations for Retirement Plans: A Moving Target, European Commission Publishes Report on Decentralized Finance. Healthcare professionals should always check this website for the most recently updated information. The AQLQ(S)+12 is a questionnaire that measures the health-related quality of life experienced by asthma subjects. PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease, an enzyme that the coronavirus needs to replicate. The studies had similar designs and measurement instruments, including the PI-NRS, collected in a daily diary, and the standard seven-point patient global impression of change (PGIC), collected at the endpoint. Case studies are in depth investigation about the particular individual, group or event. All rights reserved. 2022 Oct 14;11(10):1508. doi: 10.3390/biology11101508. 1996;65:71-76. We own and operate 500 peer-reviewed clinical, medical, life sciences, engineering, and management journals and hosts 3000 scholarly conferences per year in the fields of clinical, medical, pharmaceutical, life sciences, business, engineering and technology. NCI CPTC Antibody Characterization Program. 0 = Not assessed. They arefree and available to all participating sites. Many translated example sentences containing "clinical global impression of change" Spanish-English dictionary and search engine for Spanish translations. Percentage of missed work due to asthma is calculated by number of hours missed work due to asthma divided by total number of hours missed work plus number of hours actually worked. Mean change from baseline in home based evening PEF (L/min) at Study Week 52. Documented treatment with a total daily dose of either medium or high dose ICS ( 500 g fluticasone propionate dry powder formulation equivalent total daily dose) for at least 3 months. Bucher HC, Guyatt GH, Griffith LE, Walter SD. High and upper-middle income countries will pay more than lower income countries. As per the 2019-CTRules, IND-43, and IND-42, a sponsor (applicant) is responsible for a paying a fee to the Drugs Controller General of India (DCGI) to submit a clinical trial application.. For more on this and other developments impacting future filed data breach class actions, stay tuned. : MyPillow and Mike Lindell Facing MASSIVE EXPOSURE Alabama Medical Cannabis Application Window Is Open: [Insert Michael Ankura CTIX FLASH Update - November 1, 2022, Ankura Cyber Threat Investigations and Expert Services, Brazil Limits New Privacy Laws Obligations on Small Entities. GAS was first introduced by Kirusek and Sherman (1968) for assessing mental health outcomes. The studies had similar designs and measurement instruments, including the PI-NRS, collected in a daily diary, and the standard seven-point patient global impression of change (PGIC), collected at the endpoint. Change from baseline in ACQ-6 as compared to placebo at Week 52. The pandemic has had a devastating impact on the global economy and the health of communities across the world. Persistently positive is defined as positive at >=2 post baseline assessments (with >=16 weeks between the first and the last positive) or positive at last post baseline assessment. The latest Lifestyle | Daily Life news, tips, opinion and advice from The Sydney Morning Herald covering life and relationships, beauty, fashion, health & wellbeing In May 2018, Defendant notified certain patients that their personal information may have been involved in a data breach that occurred in December 2017. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. What is a "clinically meaningful" reduction in pain? ACQ-6 score 1.5 at screening and on day of randomization. Serial Relator Brings Multiple Lawsuits Alleging False Claims Act FTC Takes Action Against Chegg for Alleged Security Failures that Hunton Andrews Kurths Privacy and Cybersecurity, Takeaways from GAOs FY 2022 Bid Protest Report, Long Time Coming: SEC Adopts Final Dodd-Frank Clawback Rules. CGIC is a categorical scale ranging from 1 to 7, with a low score indicating clinical improvement (figure 2). The company is working to ensure access for its novel antiviral candidate for those most in need around the world, pending successful trial results and regulatory approval. The Evolving New York City Workplace: Two Important Updates Effective 5 Questions with Mike DeCesaris: AI/ML Efficiency Driven by GPUs. The Clinical Data Manager typically manages through subordinate managers and professionals in larger groups of moderate complexity. Plaintiff subsequently filed a class action complaint asserting causes of action for violation of the Customer Records Act (CRA) ( 1798.80 et seq. A daily ASD score is the mean of the 10 items. The annualized exacerbation rate is based on exacerbations reported by the investigator that are associated with hospitalization. Transiently positive is defined as having at least one post baseline ADA positive assessment and not fulfilling the conditions of persistently positive. So bereiten sich Arbeitgeber auf die elektronische New Employment Law Requirements for Companies with US-Based Employees. 85 . . The studies had similar designs and measurement instruments, including the PI-NRS, collected in a daily diary, and the standard seven-point patient global impression of change (PGIC), collected at the endpoint. Langenfeld A, Gassner AP, Wirth B, Mhlemann MB, Nyir L, Bastiaenen C, Swanenburg J. Arch Physiother. Start for free now! That it, determination of whether the patient is minimally improved or very much improved, etc, is at the discretion of the rater. Patient Global Impression of Change (PGI-C) Daily Impacts Scale [ Time Frame: Day 90 ] This questionnaire is a patient reported outcome measure. Farrar JT, Pritchett YL, Robinson M, Prakash A, Chappell A. J Pain. MeSH Deadline: 22 November 2022 Where the Semiconductor Chips Will Fall: What Manufacturers Need to Know About Are You Ready? The proportion of subjects who have no exacerbations is presented as the percentage of subjects with no exacerbations. An Updated Federal Overtime Rule: Whens It Coming? The https:// ensures that you are connecting to the The standardised objectives are a baseline for team discussion on the needs of the individual patient, and are primarily process focussed to ensure clinical issues are considered/addressed. The tool includes 30 items of therapy dependency in 7 domains; Physical handling programme, basic functions, activities of daily living, cognitive/psychosocial/family support, discharge planning, indirect interventions and additional activities, special facilities, investigations and procedures. Specifically, as alleged in the Complaint, Defendant discovered in March 2018 that a former employee had downloaded copies of information for over 5,400 patients that included insurance and clinical information before her employment ended. These guidelines recommend ways that heath and social care professionals should work to provide the best care for patients. The annualized exacerbation rate is based on exacerbations as defined for the primary endpoint, but any hospitalisation and ER visits which are adjudicated to be asthma related are added, and those adjudicated to not be asthma related are removed from analyses. Plaintiff also demanded statutory damages under the CMIA for each class member. London Tezepelumab: Tezepelumab subcutaneous injection, The annual exacerbation rate is based on unadjudicated exacerbations reported by the investigator in the eCRF. Mean serum trough PK concentrations taken pre-dose at each visit. If our candidate is successful, during the pandemic, Pfizer will offer our investigational oral antiviral therapy through a tiered pricing approach based on the income level of each country to promote equity of access across the globe. Pfizer is committed to working toward equitable access to PAXLOVID for all people, aiming to deliver safe and effective antiviral therapeutics as soon as possible and at an affordable price. The therapy dependency assessment tool is part of the parallel tranche data and should be collected at the same time as the nursing dependency score. We routinely post information that may be important to investors on our website at www.Pfizer.com. The Northwick Park Therapy Dependency Assessment Tool (NPTDA)provides a measure of therapy intervention designed for use in specialist neuro-rehabilitation settings, where high intensity rehabilitation is provided by a multi-disciplinary team. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Data on 2724 subjects from 10 recently completed placebo-controlled clinical trials of pregabalin in diabetic neuropathy, postherpetic neuralgia, chronic low back pain, fibromyalgia, and osteoarthritis were used. 3,00,000 Rupees for Phase I (human) clinical trials App. Oklahoma Telephone Solicitation Act goes into effect Chinas National Intellectual Property Administration Releases New Ninth Circuit Holds Time Spent Logging On and Off Computers May Be Employment Tip of the Month November 2022, Sizeable Increases to 2023 Plan Limits Due to Inflation. 2010 Feb;11(2):109-18. doi: 10.1016/j.jpain.2009.06.007. Cost of Living Crisis Causes Rise in Financial Crime. Last month a California appellate court affirmed (for the first time among any state appellate courts to consider the issue) the lower courts denial of class certification for claims brought under the Confidentiality of Medical Information Act (CMIA) in the wake of a data breach. ), and negligence. CGI-C means Clinical Global Impression of Change. The Scale was originally designed to be completed by a nurse or other member of the care team who regularly provides care for the patient, usually in a hospital or nursing home setting. A further description of risks and uncertainties can be found in Pfizers Annual Report on Form 10-K for the fiscal year ended December 31, 2020 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned Risk Factors and Forward-Looking Information and Factors That May Affect Future Results, as well as in its subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission and available at www.sec.gov and www.pfizer.com. We evaluated the longitudinal impact of voxelotor (Oxbryta ) in the HOPE study using the single-item Clinical Global Impression of Change (CGI-C), a validated clinician-reported outcome analogous to the commonly used Patient Global Impression of Change (PGI-C), which provides expert clinical impressions that transcend symptom checklists. Class productivity loss is derived by sum of percentage of missed class hours due to asthma and product of percentage of actual hours in class times degree of asthma affecting productivity while in class. The Barthel Index (BI) measures a persons daily functioning, particularly the activities of daily living and mobility. Used at population level, the information will enable us to quantify shortfalls in current service provision and to estimate the gap between capacity and demand for future planning. doi: 10.1002/14651858.CD007938.pub4. It is a brief 3-item observer-rated scale that can be used in clinical practice as well as in researches to track symptom changes. There are competing theories explaining hypnosis and related phenomena. Tech news and expert opinion from The Telegraph's technology team. This means treating the patient as an individual and considering what matters most to them. Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Asthma, Uncontrolled Asthma, Severe Uncontrolled Asthma, Annual Asthma Exacerbation Rate in Adult and Adolescent Patients With Uncontrolled Asthma [TimeFrame:From randomisation to Study Week 52. An official website of the United States government. Talk with your doctor and family members or friends about deciding to join a study. Sample Nurse The ASA Effective Date is Fast Approaching: Employers Should Get Commonwealth Court Restricts the Pending Ordinance Doctrine. ThePost ICU Presentation Screen(PICUPS)is a simple 14-item clinical tool developed to support triage and handover of patients stepping down from ITU into the acute wards, and onwards into rehabilitation. Cook DJ, Guyatt GH, Davis C, Willan A, McIlroy W. A diagnostic and therapeutic N-of-1 randomized trial. An ebook (short for electronic book), also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. 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